Pathogens manipulate host autophagy through injected effector proteins.
Identifieur interne : 000087 ( Main/Exploration ); précédent : 000086; suivant : 000088Pathogens manipulate host autophagy through injected effector proteins.
Auteurs : Neeraj K. Lal [États-Unis] ; Burinrutt Thanasuwat [États-Unis] ; Barry Chan [États-Unis] ; Savithramma P. Dinesh-Kumar [États-Unis]Source :
- Autophagy [ 1554-8635 ] ; 2020.
Abstract
Macroautophagy/autophagy plays a dual role in many physiological processes of multicellular eukaryotes. In plants, autophagy can be used by both host and pathogen for a beneficiary infection outcome. Plants employ a two-tier innate immune system to defend against invading pathogens. Cell surface localized pattern recognition receptors recognize conserved pathogen-associated molecular patterns (PAMPs) and launch pattern-triggered immunity (PTI) to provide broad-spectrum resistance. Pathogens inject a battery of effector proteins into their hosts to counter PTI and compromise the primary immune response. Hosts induce a second layer of defense called effector-triggered immunity (ETI) to counter the effects of these effectors. In addition to ETI and PTI, autophagy is emerging as a central cellular process modulated by both host and pathogens toward their respective advantage. Pathogens lacking the ability to inject effectors are compromised in virulence. However, molecular targets and biochemical characterization of most of these effector proteins remain elusive. In a recent paper we presented a systematic analysis of interaction between autophagy proteins of Arabidopsis thaliana with effectors from bacterial, fungal, oomycete and nematode pathogens. Abbreviations: ATG, autophagy related; BiFC, bimolecular fluorescence complementation; ETI, effector-triggered immunity; PAMPs, pathogen-associated molecular patterns; PTI, pattern-triggered immunity.
DOI: 10.1080/15548627.2020.1831816
PubMed: 33016188
Affiliations:
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Lal</name><affiliation wicri:level="2"><nlm:affiliation>Department of Plant Biology and the Genome Center, College of Biological Sciences, University of California , Davis, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Plant Biology and the Genome Center, College of Biological Sciences, University of California , Davis, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Thanasuwat, Burinrutt" sort="Thanasuwat, Burinrutt" uniqKey="Thanasuwat B" first="Burinrutt" last="Thanasuwat">Burinrutt Thanasuwat</name><affiliation wicri:level="2"><nlm:affiliation>Department of Plant Biology and the Genome Center, College of Biological Sciences, University of California , Davis, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Plant Biology and the Genome Center, College of Biological Sciences, University of California , Davis, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Chan, Barry" sort="Chan, Barry" uniqKey="Chan B" first="Barry" last="Chan">Barry Chan</name><affiliation wicri:level="2"><nlm:affiliation>Department of Plant Biology and the Genome Center, College of Biological Sciences, University of California , Davis, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Plant Biology and the Genome Center, College of Biological Sciences, University of California , Davis, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Dinesh Kumar, Savithramma P" sort="Dinesh Kumar, Savithramma P" uniqKey="Dinesh Kumar S" first="Savithramma P" last="Dinesh-Kumar">Savithramma P. Dinesh-Kumar</name><affiliation wicri:level="2"><nlm:affiliation>Department of Plant Biology and the Genome Center, College of Biological Sciences, University of California , Davis, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Plant Biology and the Genome Center, College of Biological Sciences, University of California , Davis, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author></analytic><series><title level="j">Autophagy</title><idno type="eISSN">1554-8635</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Macroautophagy/autophagy plays a dual role in many physiological processes of multicellular eukaryotes. In plants, autophagy can be used by both host and pathogen for a beneficiary infection outcome. Plants employ a two-tier innate immune system to defend against invading pathogens. Cell surface localized pattern recognition receptors recognize conserved pathogen-associated molecular patterns (PAMPs) and launch pattern-triggered immunity (PTI) to provide broad-spectrum resistance. Pathogens inject a battery of effector proteins into their hosts to counter PTI and compromise the primary immune response. Hosts induce a second layer of defense called effector-triggered immunity (ETI) to counter the effects of these effectors. In addition to ETI and PTI, autophagy is emerging as a central cellular process modulated by both host and pathogens toward their respective advantage. Pathogens lacking the ability to inject effectors are compromised in virulence. However, molecular targets and biochemical characterization of most of these effector proteins remain elusive. In a recent paper we presented a systematic analysis of interaction between autophagy proteins of <i>Arabidopsis thaliana</i> with effectors from bacterial, fungal, oomycete and nematode pathogens. <b>Abbreviations</b>: ATG, <u>a</u>u<u>t</u>opha<u>g</u>y related; BiFC, <u>b</u>imolecular <u>f</u>luorescence <u>c</u>omplementation; ETI, effector-triggered immunity; PAMPs, pathogen-associated molecular patterns; PTI, pattern-triggered immunity.</div></front></TEI><pubmed><MedlineCitation Status="Publisher" Owner="NLM"><PMID Version="1">33016188</PMID><DateRevised><Year>2020</Year><Month>10</Month><Day>15</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1554-8635</ISSN><JournalIssue CitedMedium="Internet"><PubDate><Year>2020</Year><Month>Oct</Month><Day>15</Day></PubDate></JournalIssue><Title>Autophagy</Title><ISOAbbreviation>Autophagy</ISOAbbreviation></Journal><ArticleTitle>Pathogens manipulate host autophagy through injected effector proteins.</ArticleTitle><Pagination><MedlinePgn>1-2</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1080/15548627.2020.1831816</ELocationID><Abstract><AbstractText>Macroautophagy/autophagy plays a dual role in many physiological processes of multicellular eukaryotes. In plants, autophagy can be used by both host and pathogen for a beneficiary infection outcome. Plants employ a two-tier innate immune system to defend against invading pathogens. Cell surface localized pattern recognition receptors recognize conserved pathogen-associated molecular patterns (PAMPs) and launch pattern-triggered immunity (PTI) to provide broad-spectrum resistance. Pathogens inject a battery of effector proteins into their hosts to counter PTI and compromise the primary immune response. Hosts induce a second layer of defense called effector-triggered immunity (ETI) to counter the effects of these effectors. In addition to ETI and PTI, autophagy is emerging as a central cellular process modulated by both host and pathogens toward their respective advantage. Pathogens lacking the ability to inject effectors are compromised in virulence. However, molecular targets and biochemical characterization of most of these effector proteins remain elusive. In a recent paper we presented a systematic analysis of interaction between autophagy proteins of <i>Arabidopsis thaliana</i> with effectors from bacterial, fungal, oomycete and nematode pathogens. <b>Abbreviations</b>: ATG, <u>a</u>u<u>t</u>opha<u>g</u>y related; BiFC, <u>b</u>imolecular <u>f</u>luorescence <u>c</u>omplementation; ETI, effector-triggered immunity; PAMPs, pathogen-associated molecular patterns; PTI, pattern-triggered immunity.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Lal</LastName><ForeName>Neeraj K</ForeName><Initials>NK</Initials><AffiliationInfo><Affiliation>Department of Plant Biology and the Genome Center, College of Biological Sciences, University of California , Davis, CA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Thanasuwat</LastName><ForeName>Burinrutt</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Department of Plant Biology and the Genome Center, College of Biological Sciences, University of California , Davis, CA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chan</LastName><ForeName>Barry</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Department of Plant Biology and the Genome Center, College of Biological Sciences, University of California , Davis, CA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Dinesh-Kumar</LastName><ForeName>Savithramma P</ForeName><Initials>SP</Initials><Identifier Source="ORCID">https://orcid.org/0000-0001-5738-316X</Identifier><AffiliationInfo><Affiliation>Department of Plant Biology and the Genome Center, College of Biological Sciences, University of California , Davis, CA, USA.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2020</Year><Month>10</Month><Day>15</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Autophagy</MedlineTA><NlmUniqueID>101265188</NlmUniqueID><ISSNLinking>1554-8627</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N"> Pseudomonas syringe </Keyword><Keyword MajorTopicYN="N">ATG4</Keyword><Keyword MajorTopicYN="N">ATG8</Keyword><Keyword MajorTopicYN="N">autophagy</Keyword><Keyword MajorTopicYN="N">host-microbe interaction</Keyword><Keyword MajorTopicYN="N">pathogenesis</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2020</Year><Month>10</Month><Day>6</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2020</Year><Month>10</Month><Day>6</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2020</Year><Month>10</Month><Day>5</Day><Hour>8</Hour><Minute>40</Minute></PubMedPubDate></History><PublicationStatus>aheadofprint</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">33016188</ArticleId><ArticleId IdType="doi">10.1080/15548627.2020.1831816</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>États-Unis</li></country><region><li>Californie</li></region></list><tree><country name="États-Unis"><region name="Californie"><name sortKey="Lal, Neeraj K" sort="Lal, Neeraj K" uniqKey="Lal N" first="Neeraj K" last="Lal">Neeraj K. 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